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Home  > Oral Herpes > Red marine algae benefits against herpes

Red marine algae benefits against herpes

Red marine alga has been shown to have significant inhibitory effects against herpes.

Phytomedicine 2001 Jan;8(1):53-8:

Inhibitory effect of sulfated galactans from the marine alga Bostrychia montagnei on herpes simplex virus replication in vitro.

Duarte ME, Noseda DG, Noseda MD, Tulio S, Pujol CA, Damonte EB. Departamento de Bioquimica, Universidade Federal do Parana, Centro Politecnico, Curitiba, Brasil.

"Sulfated polysaccharides exhibit many biological properties such as antiviral and anticoagulant activities. Herein, we report the antiviral activity of sulfated galactans extracted from the red sea-weed Bostrychia montagnei against herpes simplex virus types 1 (strain F and the thymidine kinase-deficient strains Field and B2006) and 2 (strain G). Two crude extracts obtained with cold and hot water as well as some fractions obtained by anion exchange chromatography, inhibited significantly the replication of the different strains of herpesviruses as determined by plaque reduction assays. The inhibitory effect of the compounds studied here took place only when they were added during the adsorption period. They were found to be highly selective antiviral substances, causing no impairment of Vero cell viability.

Furthermore, they had no direct inactivating effect on virions by incubation in a virucidal assay. The antiviral activity could be correlated with the molecular weight and sulfate content of the polysaccharides. Although sulfated polysaccharides are generally endowed with anticoagulant properties, the results of the activated partial thromboplastin time and the thrombine time assays indicated that the natural sulfated polysaccharides from Bostrychia montagnei have very low anticoagulant activity, confirming that there is no relation between the antiviral and anticoagulant properties."

Z Naturforsch 2000 Sep-Oct;55(9-10):830-5:

Antiherpes virus effect of the red marine alga Polysiphonia denudata.

Serkedjieva J. Institute of Microbiology, Bulgarian Academy of Sciences, Sofia.

"The water extract from the red marine alga Polysiphonia denudata (Dillwyn) Kutz. from the Bulgarian Black Sea coast selectively inhibited the reproduction of herpes virus type 1 and type 2 in cell cultures (EC50=8.7 to 47.7 mg/ml) as shown by the reduction of virus-induced cytopathic effect and viral infectivity. The virus-inhibitory effect was dose-related, strain-specific and depended on virus inoculum. The inhibition affected adsorption as well as the intracellular stages of viral replication. The presence of the extract throughout the whole replicative cycle was necessary for the full expression of the antiviral effect. In higher concentrations (MIC90=6.5 mg/ml) the extract exhibited strong extracellular virus inactivating activity."

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