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Other Topics: HPV and Cervical Cancer, HPV Picture Symptom Wart, HPV Vaccination, HPV Information, Pregnancy HPV, Human Papilloma Virus, Human Papilloma Virus Treatment , Mild Cervical Dysplasia, Abnormal Cell Pap Smear, Condyloma

HSR Research > Cause of cervical dysplasia

Cause of cervical dysplasia

The exact cause of cervical dysplasia is yet to be discovered. Cervical dysplasia is a precancerous condition which is described as the presence of abnormal cells in the squamous epithelium of the cervix. Cells are considered to be abnormal if they have some changes in size and shape as compared to normal cells. There are three stages of cervical dysplasia, mild, moderate and severe, which are distinguished according to the amount of abnormal cells in the epithelium. 

While the precise cause of cervical dysplasia is unclear, researchers have identified a number of risk factors for this condition. They are an early onset of sexual activity, long-term use of birth control pills, suppressed immune system, history of sexually transmitted diseases, multiple sex partners, smoking, a high number of deliveries, having a sexual partner with history of penile cancer, familial history or a genetic predisposition of developing a malignancy or premalignancy. 

There have been a lot of researchers having attempted to clarify the cause of cervical dysplasia, but there are still a lot of questions as to the development of precancerous conditions on the cervix. Cervical dysplasia has been linked to some viral infections, like Human Papilloma Virus and Herpes Simplex Virus. If the infection with these viruses is persistent, they can contribute to the transformation of the squamous and cylindrical epithelium of the cervix, causing dysplasia. One of the most important problems concerning viral etiology of dysplasia is that surgical removal of the lesions can't eliminate the virus which may remain in the body and cause abnormal cell changes.

Cervical dysplasia is often caused by Human Papilloma Virus infection. This virus is primarily transmitted through sexual intercourse. It infects epithelial cells of the cervix and may induce oncogenic changes in cells which lead to occurrence of precancerous lesions. HPV is detected in the overwhelming majority of moderate and severe cervical dysplasias, and it is considered as the main risk factor for progression of cervical dysplasia to more severe forms. Cervical cancer which develops from severe dysplasia is associated with Human Papilloma virus in almost all cases. For this reasons HPV is estimated to be the main cause of cervical dysplasia and cervical cancer.

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HPV
Cervical Dysplasia
Genital Warts
Plantar Warts
Genital Herpes
Oral Herpes
Other Conditions


Dr. Joe Glickman, Jr., M.D.

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